Human MLH1(MutL Homolog 1) ELISA Kit

Human MLH1(MutL Homolog 1) ELISA Kit

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Human MLH1 (MutL Homolog 1) ELISA Kit
MBS8803307-5x96StripWells 5x96-Strip-Wells
EUR 1710

Human MLH1 (MutL Homolog 1) ELISA Kit
MBS8803307-96StripWells 96-Strip-Wells
EUR 445

Human MutL Homolog 1 ELISA Kit (MLH1)
RK01858 96 Tests
EUR 625.2

Human MutL Homolog 1 (MLH1) ELISA Kit
20-abx152407
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human MutL Homolog 1 (MLH1) ELISA Kit
DLR-MLH1-Hu 96T
EUR 463
Description: tissue homogenates, cell lysates or other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
DLR-MLH1-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
DLR-MLH1-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
DL-MLH1-Hu 96T
EUR 441
Description: tissue homogenates, cell lysates or other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
EKN47156-48T 48T
EUR 378.7

Human MutL Homolog 1 (MLH1) ELISA Kit
EKN47156-5x96T 5x96T
EUR 2569.75

Human MutL Homolog 1 (MLH1) ELISA Kit
EKN47156-96T 96T
EUR 541

Human MutL Homolog 1 (MLH1) ELISA Kit
EK15463 96Т
EUR 768

Human MutL Homolog 1 (MLH1) ELISA Kit
EKU06045-48T 48T
EUR 555.66

Human MutL Homolog 1 (MLH1) ELISA Kit
EKU06045-5x96T 5x96T
EUR 3770.55

Human MutL Homolog 1 (MLH1) ELISA Kit
EKU06045-96T 96T
EUR 793.8

Human MutL Homolog 1 (MLH1) ELISA Kit
RDR-MLH1-Hu-48T 48T
EUR 475.34
Description: tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
RDR-MLH1-Hu-48Tests 48 Tests
EUR 652.8

Human MutL Homolog 1 (MLH1) ELISA Kit
RDR-MLH1-Hu-96T 96T
EUR 679.04
Description: tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
RDR-MLH1-Hu-96Tests 96 Tests
EUR 907.2

Human MutL Homolog 1 (MLH1) ELISA Kit
RD-MLH1-Hu-48T 48T
EUR 452.7
Description: tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
RD-MLH1-Hu-48Tests 48 Tests
EUR 625.2

Human MutL Homolog 1 (MLH1) ELISA Kit
RD-MLH1-Hu-96T 96T
EUR 646.7
Description: tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
RD-MLH1-Hu-96Tests 96 Tests
EUR 867.6

Human MutL Homolog 1 (MLH1) ELISA Kit
SEJ742Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
SEJ742Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
SEJ742Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
SEJ742Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human MutL Homolog 1 (MLH1) in tissue homogenates, cell lysates and other biological fluids.

Human MutL Homolog 1 (MLH1) ELISA Kit
4-SEJ742Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human MutL Homolog 1 (MLH1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2022593-10x96StripWells 10x96-Strip-Wells
EUR 5320

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2022593-24StripWells 24-Strip-Wells
EUR 360

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2022593-48StripWells 48-Strip-Wells
EUR 545

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2022593-5x96StripWells 5x96-Strip-Wells
EUR 2915

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2022593-96StripWells 96-Strip-Wells
EUR 720

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS4501050-10x96Tests 10x96Tests
EUR 5260

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS4501050-48Tests 48Tests
EUR 460

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS4501050-5x96Tests 5x96Tests
EUR 2700

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS4501050-96Test 96Test
EUR 605

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2706758-10x96StripWells 10x96-Strip-Wells
EUR 3130

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2706758-24StripWells 24-Strip-Wells
EUR 255

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2706758-48StripWells 48-Strip-Wells
EUR 330

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2706758-5x96StripWells 5x96-Strip-Wells
EUR 1630

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS2706758-96StripWells 96-Strip-Wells
EUR 420

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS452937-10x96StripWells 10x96-Strip-Wells
EUR 5050

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS452937-48StripWells 48-Strip-Wells
EUR 440

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS452937-5x96StripWells 5x96-Strip-Wells
EUR 2590

Human MutL Homolog 1 (MLH1) ELISA Kit
MBS452937-96StripWells 96-Strip-Wells
EUR 585

ELISA kit for Human MLH1 (MutL Homolog 1)
ELK4307 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of MutL Homolog 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human MutL Homolog 1 (MLH1) CLIA Kit
20-abx495774
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ELISA Kit for MutL Homolog 1 (MLH1)
SEJ742Hu 96Т
EUR 700

Rat MutL Homolog 1 (MLH1) ELISA Kit
abx533185-96tests 96 tests
EUR 687.5

Plant MutL Homolog 1 (MLH1) ELISA Kit
MBS9380661-INQUIRE INQUIRE Ask for price

MLH1 (MutL Homolog 1)
MO47010 100 ul
EUR 418.8

MLH1 (MutL Homolog 1)
MBS4381087-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

MLH1 (MutL Homolog 1)
MBS4381087-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

MLH1 (MutL Homolog 1)
MBS4381087-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

MLH1 (MutL Homolog 1)
MBS4381087-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

MLH1 (MutL Homolog 1)
MBS4381087-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

MLH1 (MutL Homolog 1)
MBS556109-01mL 0.1mL
EUR 455

MLH1 (MutL Homolog 1)
MBS556109-5x01mL 5x0.1mL
EUR 1895

Human MutL Homolog 1 (MLH1) Protein
20-abx654421
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human MutL Homolog 1 (MLH1) Protein
abx654421-20g 20 µg
EUR 337.5

Human MutL Homolog 1 (MLH1) Protein
abx654421-5g 5 µg
EUR 200

MLH1 (MutL Homolog 1)(MLH1/1324), 0.2mg/mL
BNUB1324-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), 0.2mg/mL
BNUB1324-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), 1mg/mL
BNUM1324-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MutL Homolog 1 (MLH1) Antibody
20-abx113897
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  • 150 ul
  • 50 ul

MutL Homolog 1 (MLH1) Antibody
20-abx002899
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  • 100 ul
  • 200 ul

MutL Homolog 1 (MLH1) Antibody
abx012221-100ul 100 ul
EUR 493.2

MutL Homolog 1 (MLH1) Antibody
abx025515-100ul 100 ul
EUR 627.6

MutL Homolog 1 (MLH1) Antibody
abx026385-400ul 400 ul
EUR 627.6

MutL Homolog 1 (MLH1) Antibody
abx026385-80l 80 µl
EUR 343.2

MutL Homolog 1 (MLH1) Antibody
20-abx008989
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  • 100 ul
  • 200 ul
  • 30 ul

MutL Homolog 1 (MLH1) Antibody
20-abx014046
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  • 100 ug
  • 10 ug
  • 200 ug
  • 20 ug
  • 300 µg

MutL Homolog 1 (MLH1) Antibody
20-abx000639
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

MutL Homolog 1 (MLH1) Antibody
abx235213-100ug 100 ug
EUR 577.2

MutL Homolog 1 (MLH1) Antibody
20-abx173641
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  • 1 mg
  • 200 ug

MutL Homolog 1 (MLH1) Antibody
20-abx177638
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  • 1 mg
  • 200 ug

MutL Homolog 1 (MLH1) Antibody
20-abx328114
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  • 100 ug
  • 50 ug

MutL Homolog 1 (MLH1) Antibody
20-abx241566
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  • 100 ul
  • 50 ul

MutL Homolog 1 (MLH1) Antibody
20-abx241567
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  • 100 ul
  • 50 ul

MutL Homolog 1 (MLH1) Antibody
20-abx317973
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

MutL Homolog 1 (MLH1) Antibody
abx113897-100l 100 µl
EUR 612.5

MutL Homolog 1 (MLH1) Antibody
abx026385-400l 400 µl
EUR 518.75

MutL Homolog 1 (MLH1) Antibody
abx025515-400l 400 µl Ask for price

MutL Homolog 1 (MLH1) Antibody
abx025515-80l 80 µl
EUR 518.75

MutL Homolog 1 (MLH1) Antibody
abx235213-100g 100 µg
EUR 350

MutL Homolog 1 (MLH1) Antibody
abx241566-96tests 96 tests
EUR 250

MutL Homolog 1 (MLH1) Antibody
abx241567-96tests 96 tests
EUR 250

MutL Homolog 1 (MLH1) Antibody
abx328114-100g 100 µg
EUR 250

MutL Homolog 1 (MLH1) Antibody
abx328114-50g 50 µg
EUR 187.5

MutL Homolog 1 (MLH1) Antibody
abx317973-100g 100 µg
EUR 362.5

MutL Homolog 1 (MLH1) Antibody
abx317973-20g 20 µg
EUR 162.5

MutL Homolog 1 (MLH1) Antibody
abx317973-50g 50 µg
EUR 250

MutL Homolog 1 (MLH1) Antibody
abx014046-100l 100 µl
EUR 43.75

MutL Homolog 1 (MLH1) Antibody
abx012221-100g 100 µg Ask for price

MutL Homolog 1 (MLH1) Antibody
abx012221-10g 10 µg
EUR 362.5

MutL Homolog 1 (MLH1) Antibody
abx012221-200g 200 µg Ask for price

MutL Homolog 1 (MLH1) Antibody
abx000639-100l 100 µl
EUR 387.5

MutL Homolog 1 (MLH1) Antibody
abx000639-20l 20 µl
EUR 175

MutL Homolog 1 (MLH1) Antibody
abx000639-50l 50 µl
EUR 275

MLH1 Antibody / MutL Homolog 1
V8749-100UG 100 ug
EUR 349.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V8749-20UG 20 ug
EUR 153.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V8749SAF-100UG 100 ug
EUR 349.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V9166-100UG 100ug
EUR 424.15
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V9166-20UG 20ug
EUR 186.15
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V9166SAF-100UG 100ug
EUR 424.15
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4038-100UG 100 ug
EUR 349.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4038-20UG 20 ug
EUR 153.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4038SAF-100UG 100 ug
EUR 349.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V9349-100UG 100ug
EUR 349.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V9349-20UG 20ug
EUR 153.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V9349SAF-100UG 100ug
EUR 349.3
Description: This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4970-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4970-20UG 20ug
EUR 160.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4970SAF-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4971-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4971-20UG 20ug
EUR 160.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4971SAF-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4972-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4972-20UG 20ug
EUR 160.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4972SAF-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4973-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4973-20UG 20ug
EUR 160.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4973SAF-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4974-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4974-20UG 20ug
EUR 160.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

MLH1 Antibody / MutL Homolog 1
V4974SAF-100UG 100ug
EUR 363.3
Description: This mAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2). Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

Recombinant MutL Homolog 1 (MLH1)
RPJ742Hu01 10ug
EUR 140

Recombinant MutL Homolog 1 (MLH1)
RPJ742Hu02 10ug
EUR 143

Recombinant MutL Homolog 1 (MLH1)
RPJ742Hu03 10ug
EUR 144

Recombinant MutL Homolog 1 (MLH1)
MBS2139860-001mg 0.01mg
EUR 155

Recombinant MutL Homolog 1 (MLH1)
MBS2139860-005mg 0.05mg
EUR 260

Recombinant MutL Homolog 1 (MLH1)
MBS2139860-01mg 0.1mg
EUR 375

Recombinant MutL Homolog 1 (MLH1)
MBS2139860-02mg 0.2mg
EUR 460

Recombinant MutL Homolog 1 (MLH1)
MBS2139860-05mg 0.5mg
EUR 860

Human MLH3(MutL Homolog 3) ELISA Kit
ELK7522-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MLH3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MLH3. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MLH3, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MLH3 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human MLH3(MutL Homolog 3) ELISA Kit
ELK7522-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MLH3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MLH3. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MLH3, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MLH3 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human MLH3 (MutL Homolog 3) ELISA Kit
MBS8806499-10x96StripWells 10x96-Strip-Wells
EUR 3130

Human MLH3 (MutL Homolog 3) ELISA Kit
MBS8806499-48StripWells 48-Strip-Wells
EUR 350

Human MLH3 (MutL Homolog 3) ELISA Kit
MBS8806499-5x96StripWells 5x96-Strip-Wells
EUR 1710

Human MLH3 (MutL Homolog 3) ELISA Kit
MBS8806499-96StripWells 96-Strip-Wells
EUR 445

MutL Homolog 1 (MLH1) Antibody (HRP)
20-abx313263
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  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

MutL Homolog 1 (MLH1) Antibody (HRP)
abx313263-100g 100 µg
EUR 362.5

MutL Homolog 1 (MLH1) Antibody (HRP)
abx313263-20g 20 µg
EUR 162.5

MutL Homolog 1 (MLH1) Antibody (HRP)
abx313263-50g 50 µg
EUR 250

MutL Homolog 1 (MLH1) Antibody (FITC)
20-abx313264
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

MutL Homolog 1 (MLH1) Antibody (FITC)
abx313264-100g 100 µg
EUR 362.5

MutL Homolog 1 (MLH1) Antibody (FITC)
abx313264-20g 20 µg
EUR 162.5

MutL Homolog 1 (MLH1) Antibody (FITC)
abx313264-50g 50 µg
EUR 250

MutL Homolog 1 (MLH1) Antibody (Biotin)
20-abx313265
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

MutL Homolog 1 (MLH1) Antibody (Biotin)
abx313265-100g 100 µg
EUR 362.5

MutL Homolog 1 (MLH1) Antibody (Biotin)
abx313265-20g 20 µg
EUR 162.5

MutL Homolog 1 (MLH1) Antibody (Biotin)
abx313265-50g 50 µg
EUR 250

MLH1 (MutL Homolog 1)(MLH1/1324), CF594 conjugate, 0.1mg/mL
BNC941324-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), CF594 conjugate, 0.1mg/mL
BNC941324-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), CF647 conjugate, 0.1mg/mL
BNC471324-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), CF647 conjugate, 0.1mg/mL
BNC471324-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), CF568 conjugate, 0.1mg/mL
BNC681324-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), CF568 conjugate, 0.1mg/mL
BNC681324-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), CF405S conjugate, 0.1mg/mL
BNC041324-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), CF405S conjugate, 0.1mg/mL
BNC041324-500 1uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

MLH1 (MutL Homolog 1)(MLH1/1324), CF488A conjugate, 0.1mg/mL
BNC881324-100 1uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Human MLH1(MutL Homolog 1) ELISA Kit